Therapeutic Areas Doctors & Pharmacists

Urology

The urology preparations of A. Menarini Pharma cover the indication areas ejaculatio praecox and erectile dysfunction. The short-acting serotonin reuptake inhibitor dapoxetine (Priligy^®) is currently the only approved oral medication for the most common male sexual dysfunction, premature ejaculation.¹ The ejaculatory reflex is triggered by physical and psychological processes in the central nervous system. The neurotransmitter serotonin plays an important role in this process.² Dapoxetine, the active ingredient in Priligy^®, reduces the reuptake of serotonin into the nerve cells so that serotonin can act longer at the membrane receptors.³ Studies have shown that serotonin reuptake inhibitors such as Priligy®^® can delay ejaculation.²

The PDE-5 inhibitor avanafil (Spedra^®) is the 4th member of its class¹ and has been approved since 2013. The drug contains the active ingredient avanafil. It belongs to the drug group of "phosphodiesterase-5 (PDE5) inhibitors". Spedra^® is used to treat adult men suffering from erectile dysfunction. The drug helps smooth muscle in the penis to relax, resulting in blood inflow and an erection.⁴

References: 1 Salonia et al, Eur Urol. 2021;80(3):333-357, 2 McCarty EJ et al, Core Evidence 2012; 7: 1-14, 3 Drug information Priligy^®, 4 Drug information Spedra^®

AT-WEB-44-10-2021